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figure

Pathway diagram for APOE4

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File not found on disk

46 nodes, 47 edges

p-debate-20260410-110241-04eef441/pathway_APOE4_7d57408c.svg

Related Entities

APOE4 amyloid beta deposits dense-core plaques cerebral amyloid angiopathy neural connectivity pathways microRNAs cognition amyloid pathology endothelial integrity glaucoma lipid droplets endolysosomal trafficking mitochondrial metabolism innate immune pathways amyloid-β tau neuroinflammation lipid transport glucose metabolism cerebrovascular function TARDBP JUN APOE ABCA1 sex brain lipid composition cognitive decline TREM2 CGAS NMDA receptor apoER2 dimerization amyloid β-peptide APP LGALS3 INPP5D energy metabolism neurite damage cholesterol transport NFL triglyceride transport TLR4/NF-κB pathway MMP9 LXRβ/ABCA1 pathway cholesterol efflux oxidized unsaturated lipids

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