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figure

Pathway diagram for TDP-43

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File not found on disk

45 nodes, 45 edges

-debate-20260410-112945-6a9ce0a3/pathway_TDP-43_fcce9955.svg

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TDP-43 mitochondrial DNA mitochondrial permeability transition pore type I interferon mPTP frontotemporal lobar degeneration progranulin neuron translation fidelity TARDBP RNA splicing APOE4 cognitive impairment GGGGCC repeat RNA lysosomal dysfunction NEAT1 RNA metabolism proteostasis axonal transport motor cortex C9orf72 cytoplasmic aggregation nuclear-to-cytoplasmic transport ANXA11 CSNK1D Proteostatic Collapse CGAS STING SQSTM1 TFEB APOE FUS PROTEOSTASIS MTOR PINK1 VCP TAU GRN SOD1 Motor Neuron Degeneration LC3ylation ATG4B Cryptic Splicing Neural Tissue UNC13A

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