C9orf72-like transcriptional signature in layer 5 pyramidal neurons marks AD-TDP co-pathology. A subset of deep layer excitatory neurons shows increased ATXN2 upregulation, RAN stress markers, and cytoplasmic TDP-43 mislocalization genes, suggesting common RNA metabolism disruption across FTLD-TDP and AD.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
MMP9["MMP9"] -->|causes| BBB_breakdown["BBB breakdown"]
MMP9_1["MMP9"] -->|causes| Tau_Propagation["Tau Propagation"]
Vascular_Dysfunction["Vascular Dysfunction"] -->|causes| Tau_Propagation_2["Tau Propagation"]
CSF1R["CSF1R"] -->|regulates| neuroinflammation["neuroinflammation"]
apoe4["apoe4"] -->|causes| microglial_inflammation["microglial inflammation"]
TREM2_deficiency["TREM2 deficiency"] -->|causes| alternative_DAM_activatio["alternative DAM activation"]
ER_Stress["ER Stress"] -->|causes| Neuronal_Vulnerability["Neuronal Vulnerability"]
EIF2AK3["EIF2AK3"] -->|regulates| UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
mitochondrial_dysfunction["mitochondrial_dysfunction"] -->|causes| Neuronal_Vulnerability_3["Neuronal Vulnerability"]
PDGFRA["PDGFRA"] -->|causes| OPC_maturation_arrest["OPC maturation arrest"]
OPC_maturation_arrest_4["OPC maturation arrest"] -->|causes| Demyelination["Demyelination"]
TDP_43["TDP-43"] -->|associated with| AD_TDP_co_pathology["AD-TDP co-pathology"]
style MMP9 fill:#ce93d8,stroke:#333,color:#000
style BBB_breakdown fill:#4fc3f7,stroke:#333,color:#000
style MMP9_1 fill:#ce93d8,stroke:#333,color:#000
style Tau_Propagation fill:#4fc3f7,stroke:#333,color:#000
style Vascular_Dysfunction fill:#4fc3f7,stroke:#333,color:#000
style Tau_Propagation_2 fill:#4fc3f7,stroke:#333,color:#000
style CSF1R fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
style apoe4 fill:#ef5350,stroke:#333,color:#000
style microglial_inflammation fill:#4fc3f7,stroke:#333,color:#000
style TREM2_deficiency fill:#4fc3f7,stroke:#333,color:#000
style alternative_DAM_activatio fill:#4fc3f7,stroke:#333,color:#000
style ER_Stress fill:#4fc3f7,stroke:#333,color:#000
style Neuronal_Vulnerability fill:#4fc3f7,stroke:#333,color:#000
style EIF2AK3 fill:#ce93d8,stroke:#333,color:#000
style UNFOLDED_PROTEIN_RESPONSE fill:#ce93d8,stroke:#333,color:#000
style mitochondrial_dysfunction fill:#4fc3f7,stroke:#333,color:#000
style Neuronal_Vulnerability_3 fill:#4fc3f7,stroke:#333,color:#000
style PDGFRA fill:#ce93d8,stroke:#333,color:#000
style OPC_maturation_arrest fill:#4fc3f7,stroke:#333,color:#000
style OPC_maturation_arrest_4 fill:#4fc3f7,stroke:#333,color:#000
style Demyelination fill:#81c784,stroke:#333,color:#000
style TDP_43 fill:#4fc3f7,stroke:#333,color:#000
style AD_TDP_co_pathology fill:#ef5350,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for TARDBP.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.