VEGF-family genetic control of vascular-neuronal coupling in vulnerable hippocampal regions should produce a measurable proximal phenotype before late disease pathology. The decisive test is spatial transcriptomics plus vascular imaging ordered against amyloid and tau burden across hippocampal subfields.
Curated pathway from expert analysis
flowchart TD
A["VEGF Family GWAS Signals<br/>AD Risk Alleles in VEGFA, FLT1, KDR"]
B["Angiogenesis and Vascular Remodeling<br/>Blood-Brain Barrier Integrity"]
C["Vascular-Neuronal Coupling Disruption<br/>Hippocampal CA1 and Subiculum"]
D["Neurovascular Unit Stress<br/>Pericyte and Astrocyte End-foot Dysfunction"]
E["Tau Propagation Acceleration<br/>Neuronal Vulnerability Increased"]
F["AD Cognitive Decline<br/>Memory Consolidation Failure"]
A --> B
B --> C
C --> D
D --> E
E --> F
style A fill:#0d47a1,stroke:#64b5f6,color:#64b5f6
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9aNo linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for VEGF yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for VEGF.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.