OPCs show failure to differentiate due to elevated PDGFRA oscillation and hypomethylation of maturation genes. OPCs in AD brains show sustained PDGFRA expression, reduced MBP and PLP1, and epigenetic silencing of myelin genes, reflecting maturation arrest contributing to demyelination independent of primary oligodendrocyte loss.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
PDGFRA["PDGFRA"] -->|causes| OPC_maturation_arrest["OPC maturation arrest"]
PDGFRA_1["PDGFRA"] -.->|inhibits| OPC_differentiation["OPC differentiation"]
PDGFRA_oscillation["PDGFRA oscillation"] -->|causes| OPC_maturation_arrest_2["OPC maturation arrest"]
style PDGFRA fill:#ce93d8,stroke:#333,color:#000
style OPC_maturation_arrest fill:#4fc3f7,stroke:#333,color:#000
style PDGFRA_1 fill:#ce93d8,stroke:#333,color:#000
style OPC_differentiation fill:#4fc3f7,stroke:#333,color:#000
style PDGFRA_oscillation fill:#4fc3f7,stroke:#333,color:#000
style OPC_maturation_arrest_2 fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for PDGFRA yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for PDGFRA.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.