HDAC6 deacetylates α-tubulin and regulates cytoskeletal dynamics. HDAC6 overexpression causes axonal transport defects. Selective HDAC6 inhibition restores acetylated tubulin levels, improves axonal transport, and delays disease progression in CMT2A and SOD1 mouse models.
No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for HDAC6 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for HDAC6.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.