Aberrant arginine methylation prevents TDP-43 liquid-liquid phase separation, promoting pathogenic aggregation. PRMT5-mediated asymmetric dimethylation of RGG motifs in TDP-43 normally maintains phase separation competence. Under stress, hypomethylation or excessive methylation both disrupt LLPS, causing TDP-43 to transition from liquid droplets directly to solid aggregates.
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No curated PDB or AlphaFold mapping for TDP-43 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for TDP-43 (TARDBP), PRMT5.
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