The question is likely underpowered or misleading unless analyses preserve the key strata: DPP6, GWAS. Averaging across these strata could convert a causal subpopulation effect into a weak association.
Curated pathway from expert analysis
flowchart TD
A["DPP6 GWAS Signal<br/>PD Cognitive Risk Locus"]
B["Neuronal Potassium Channel States<br/>K+ Current Properties in Subtypes"]
C["Synaptic Excitability Regulation<br/>Dendritic Integration State"]
D["Cognitive Resilience Mechanism<br/>Executive Function Preservation"]
E["Cell-State Stratification<br/>Vulnerable vs Resilient Neuronal Populations"]
F["PD Cognitive Preservation<br/>Targeted DPP6 Modulation Strategy"]
A --> B
B --> C
C --> D
D --> E
E --> F
style A fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9aNo linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for GWAS yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for GWAS.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.