The question is likely underpowered or misleading unless analyses preserve the key strata: amyloid-beta. Averaging across these strata could convert a causal subpopulation effect into a weak association.
Curated pathway from expert analysis
flowchart TD
A["Microglial State Atlas<br/>DAM, RIM, and Intermediate States"]
B["Sex as Biological Variable<br/>X-Chromosome Dose Effect on Microglia"]
C["Amyloid vs Tau Pathology<br/>State-Specific Microglial Responses"]
D["Cognitive Decline Trajectory<br/>Sex-Dimorphic Progression Pattern"]
E["Stratified Therapeutic Targeting<br/>State and Sex-Specific Intervention"]
F["AD Precision Medicine<br/>Personalized Microglial State Targeting"]
A --> B
B --> C
C --> D
D --> E
E --> F
style A fill:#4a148c,stroke:#ce93d8,color:#ce93d8
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9aNo linked papers recorded for this hypothesis yet.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for this gene.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.