C9orf72 repeat expansions produce toxic dipeptide repeats (DPRs) that impair nucleocytoplasmic transport and autophagy. mTOR inhibition via rapamycin may reduce DPR accumulation. However, rapamycin benefits in Drosophila C9 models did not translate well to mammals, and C9 ASO programs have failed clinically.
No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for MTOR yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for MTOR.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.