Oligodendrocyte Precursor Cell Activation to Restore Structural Connectome Integrity
Curated pathway from expert analysis
flowchart TD
A["Oligodendrocyte Precursor Cell<br/>Hypothesis Target"]
B["Pathway Dysregulation<br/>Cited Mechanism"]
C["Cellular Response<br/>Stress or Clearance Change"]
D["Neural Circuit Effect<br/>Synapse/Glia Vulnerability"]
E["Neurodegeneration<br/>Disease-Relevant Outcome"]
A --> B
B --> C
C --> D
D --> E
style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
style B fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
style E fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9aNo linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for OLIGODENDROCYTE yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for Oligodendrocyte Precursor Cell.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
| Prediction | Predicted | Observed | Status | Conf |
|---|---|---|---|---|
| IF aged (18-month) APP/PS1 Alzheimer's disease model mice receive voluntary wheel running (access 24h/day for 12 weeks) to endogenously activate OPCs, THEN stereological OPC counts in subcortical whit | Increased PDGFRα+ OPC density (criterion: >800 cells/mm² in corpus callosum) and restored structural connectome topology with normalized small-worldness index ( | — no observation — | pending | 0.45 |
| IF adult mice with cuprizone-induced demyelination receive daily intraperitoneal clemastine (10 mg/kg) for 4 weeks to pharmacologically activate OPCs, THEN quantitative measures of corpus callosum mye | Remyelination of demyelinated axons with g-ratio normalization (approaching 0.7-0.8 range) and restoration of DTI FA values to ≥90% of baseline pre-demyelinatio | — no observation — | pending | 0.55 |