flowchart TD
    A["NTRK1/TrkA Receptor<br/>Neurotrophin Tyrosine Kinase"]
    B["NGF Binding<br/>Dimerization and Autophosphorylation"]
    C["PI3K/AKT Pathway<br/>Survival Signal Cascade"]
    D["MAPK/ERK Pathway<br/>Neuronal Differentiation"]
    E["PLCgamma1 Activation<br/>Calcium Signaling Cascade"]
    F["TrkA Internalization<br/>Endosomal Signaling"]
    G["Sustained AKT Signaling<br/>Pro-Survival Outcome"]
    H["Tau Phosphorylation<br/>ERK-Mediated GSK3B"]
    I["Neuronal Apoptosis<br/>Survival Signal Loss"]
    A --> B
    B --> C
    B --> D
    B --> E
    C --> F
    F --> G
    D --> H
    G -->|"blocks"| I
    H -.->|"contributes"| I
    style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style I fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a