Small-molecule inhibitor targeting p38γ (MAPK12) to prevent tau phosphorylation at Ser396/404, reducing neurofibrillary tangle formation. Strong mechanistic data but challenged by kinase selectivity barriers, p38 inhibitor class failures in prior AD trials, and high development costs.
No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for MAPK12 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for MAPK12.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.