graph TD
    NRF2["NRF2"] -->|regulates| ARE_gene_transcription["ARE gene transcription"]
    NFE2L2["NFE2L2"] -->|regulates| ARE_gene_transcription_1["ARE gene transcription"]
    NRF2_activation["NRF2 activation"] -->|protective against| neurodegenerative_disease["neurodegenerative diseases"]
    NRF2_nuclear_localization["NRF2 nuclear localization"] -->|biomarker for| Alzheimer_s_disease["Alzheimer's disease"]
    NQO1["NQO1"] -->|regulates| redox_homeostasis["redox homeostasis"]
    HO_1["HO-1"] -->|regulates| redox_homeostasis_2["redox homeostasis"]
    TREM2["TREM2"] -->|regulates| microglial_metabolic_repr["microglial metabolic reprogramming"]
    TREM2_deficiency["TREM2 deficiency"] -->|causes| impaired_amyloid_plaque_e["impaired amyloid plaque enclosure"]
    TREM2_agonism["TREM2 agonism"] -->|protective against| amyloid_associated_neurot["amyloid-associated neurotoxicity"]
    neuronal_activity["neuronal activity"] -->|regulates| tau_propagation["tau propagation"]
    CDK5["CDK5"] -->|regulates| tau_packaging_into_exosom["tau packaging into exosomes"]
    NLRP3_inflammasome_activa["NLRP3 inflammasome activation"] -->|causes| IL_1__release["IL-1β release"]
    style NRF2 fill:#ce93d8,stroke:#333,color:#000
    style ARE_gene_transcription fill:#81c784,stroke:#333,color:#000
    style NFE2L2 fill:#ce93d8,stroke:#333,color:#000
    style ARE_gene_transcription_1 fill:#4fc3f7,stroke:#333,color:#000
    style NRF2_activation fill:#4fc3f7,stroke:#333,color:#000
    style neurodegenerative_disease fill:#ef5350,stroke:#333,color:#000
    style NRF2_nuclear_localization fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#000
    style NQO1 fill:#4fc3f7,stroke:#333,color:#000
    style redox_homeostasis fill:#4fc3f7,stroke:#333,color:#000
    style HO_1 fill:#4fc3f7,stroke:#333,color:#000
    style redox_homeostasis_2 fill:#4fc3f7,stroke:#333,color:#000
    style TREM2 fill:#4fc3f7,stroke:#333,color:#000
    style microglial_metabolic_repr fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_deficiency fill:#4fc3f7,stroke:#333,color:#000
    style impaired_amyloid_plaque_e fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_agonism fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_associated_neurot fill:#4fc3f7,stroke:#333,color:#000
    style neuronal_activity fill:#4fc3f7,stroke:#333,color:#000
    style tau_propagation fill:#4fc3f7,stroke:#333,color:#000
    style CDK5 fill:#4fc3f7,stroke:#333,color:#000
    style tau_packaging_into_exosom fill:#4fc3f7,stroke:#333,color:#000
    style NLRP3_inflammasome_activa fill:#4fc3f7,stroke:#333,color:#000
    style IL_1__release fill:#4fc3f7,stroke:#333,color:#000