Chelation of redox-active metals and suppression of oxidative cross-linking reduce formation of toxic tau oligomers rather than binding mature fibrils directly.
Curated pathway from expert analysis
flowchart TD
A["Target Gene: MAPT"]
B["Molecular Mechanism<br/>Pathway Activation"]
C["Cellular Phenotype<br/>Neuronal / Glial Response"]
D["Network Effect<br/>Circuit-Level Consequence"]
E["Disease Relevance<br/>Neurodegeneration Link"]
A --> B --> C --> D --> E
style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
style E fill:#1b5e20,stroke:#81c784,color:#81c784No linked papers recorded for this hypothesis yet.
Median TPM across 13 brain regions for MAPT from GTEx v10.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for MAPT.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
| Prediction | Predicted | Observed | Status | Conf |
|---|---|---|---|---|
| IF recombinant human 2N4R tau monomers (10 μM) are incubated with CuCl₂ (25 μM) plus H₂O₂ (100 μM) in the presence of rutin (100 μM), THEN the concentration of tau oligomers (measured by oligomer-spec | ≥50% reduction in tau oligomer concentration with no change in fibril elongation rate | — no observation — | pending | 0.72 |
| IF HEK293T cells transiently expressing 3×FLAG-hTau40 are pre-treated with rutin (30 μM) for 1 hour before exposure to 50 μM H₂O₂ for 2 hours, THEN intracellular tau oligomers (measured by amplified l | ≥40% reduction in oxidatively-induced tau oligomers with preserved total tau expression | — no observation — | pending | 0.68 |