H3K9me3 Heterochromatin Loss at Pericentromeric Repeats
Curated pathway from expert analysis
flowchart TD
A["H3K9me3 Heterochromatin<br/>Hypothesis Target"]
B["Pathway Dysregulation<br/>Cited Mechanism"]
C["Cellular Response<br/>Stress or Clearance Change"]
D["Neural Circuit Effect<br/>Synapse/Glia Vulnerability"]
E["Neurodegeneration<br/>Disease-Relevant Outcome"]
A --> B
B --> C
C --> D
D --> E
style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
style B fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
style E fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9aNo linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for H3K9ME3 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for H3K9me3 Heterochromatin.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
| Prediction | Predicted | Observed | Status | Conf |
|---|---|---|---|---|
| IF Drosophila expressing human α-synuclein (UAS-αSyn) under pan-neuronal driver are crossed with Setdb1 overexpression line (UAS-Setdb1) to achieve co-expression, THEN median survival will increase by | H3K9me3 levels at Drosophila pericentromeric satellite repeats (determined by ChIP-qPCR) will be maintained at near-wildtype levels (≤20% reduction from control | — no observation — | pending | 0.55 |
| IF primary cortical neurons from aged (>18 months) C57BL/6 mice are treated with SIRT1 inhibitor EX-527 (100 μM, 48h), THEN H3K9me3 enrichment at major satellite repeats (measured by ChIP-qPCR with pr | ≥50% reduction in H3K9me3 at pericentromeric repeats, accompanied by ≥2-fold increase in major satellite transcript levels (qRT-PCR) and ≥1.5-fold elevation in | — no observation — | pending | 0.65 |