Claims from this analysis should be evaluated across APOE, AD, tau, amyloid; pooled effects are insufficient when causal direction, cell state, genotype, benchmark leakage, or reproducibility risks can dominate the result.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
APOE4["APOE4"] -->|risk factor for| AD["AD"]
lipid_dysregulation["lipid dysregulation"] -->|drives| AD_pathology["AD pathology"]
synaptic_phagocytosis["synaptic phagocytosis"] -->|drives| AD_pathology_1["AD pathology"]
APOE_genotype["APOE genotype"] -->|associated with| AD_2["AD"]
amyloid["amyloid"] -->|biomarker for| AD_3["AD"]
sess_AD_MASTER_PLAN_APOE_["sess_AD-MASTER-PLAN-APOE-20260428030754_task_66f1207e_ctx"] -->|causal extracted| processed["processed"]
style APOE4 fill:#ce93d8,stroke:#333,color:#000
style AD fill:#ef5350,stroke:#333,color:#000
style lipid_dysregulation fill:#4fc3f7,stroke:#333,color:#000
style AD_pathology fill:#4fc3f7,stroke:#333,color:#000
style synaptic_phagocytosis fill:#4fc3f7,stroke:#333,color:#000
style AD_pathology_1 fill:#4fc3f7,stroke:#333,color:#000
style APOE_genotype fill:#ce93d8,stroke:#333,color:#000
style AD_2 fill:#ef5350,stroke:#333,color:#000
style amyloid fill:#4fc3f7,stroke:#333,color:#000
style AD_3 fill:#ef5350,stroke:#333,color:#000
style sess_AD_MASTER_PLAN_APOE_ fill:#4fc3f7,stroke:#333,color:#000
style processed fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for AD yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for AD.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.