Circadian Rhythm Amplification to Restore Network Oscillation Synchronization
Curated pathway from expert analysis
flowchart TD
A["Circadian Rhythm<br/>Amplification Intervention"]
B["SCN Pacemaking Neurons<br/>Oscillation Strength"]
C["Network Oscillation<br/>Synchronization Restored"]
D["BMAL1/CLOCK<br/>Clock Gene Activation"]
E["Sleep-Wake Cycle<br/>Normalization"]
F["Neurodegeneration<br/>Progression Slowed"]
G["Circadian Amplification<br/>as Network Stabilizer"]
A --> B
B --> C
C --> D
D --> E
E --> F
G -.->|"sustains"| B
style A fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
style F fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for CIRCADIAN yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for Circadian Rhythm Amplification.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
| Prediction | Predicted | Observed | Status | Conf |
|---|---|---|---|---|
| IF we stratify participants based on circadian amplitude quartiles (bottom 25% vs top 25%) using 14-day ambulatory actigraphy monitoring, THEN the low circadian amplitude subgroup will exhibit reduced | Low circadian amplitude group shows ≥25% lower beta-band coherence (frontal-to-temporal) and ≥30% lower theta-gamma coupling index relative to high amplitude gr | — no observation — | pending | 0.45 |
| IF we pharmacologically amplify circadian rhythm amplitude using timed melatonin receptor agonists (e.g., tasimelteon) combined with morning bright light therapy in adults aged 55-75 with documented n | Mean PLV increase of ≥0.15 in the 0.1-0.4 Hz frequency band measured via high-density EEG during working memory tasks | — no observation — | pending | 0.50 |