The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun evidence should precede promotion into Atlas or market funding.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
microglial_dysfunction["microglial dysfunction"] -->|causes| tau_pathology["tau pathology"]
TREM2["TREM2"] -.->|inhibits| tau_spread["tau spread"]
TREM2_1["TREM2"] -.->|inhibits| tau_propagation["tau propagation"]
protective_microglial_res["protective microglial response"] -->|protective against| tau_pathology_2["tau pathology"]
style microglial_dysfunction fill:#4fc3f7,stroke:#333,color:#000
style tau_pathology fill:#4fc3f7,stroke:#333,color:#000
style TREM2 fill:#ce93d8,stroke:#333,color:#000
style tau_spread fill:#4fc3f7,stroke:#333,color:#000
style TREM2_1 fill:#ce93d8,stroke:#333,color:#000
style tau_propagation fill:#4fc3f7,stroke:#333,color:#000
style protective_microglial_res fill:#4fc3f7,stroke:#333,color:#000
style tau_pathology_2 fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for TAU yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for tau.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.