The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun evidence should precede promotion into Atlas or market funding.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
LRP1_mediated_tau_uptake_["LRP1-mediated tau uptake disruption"] -->|causes| early_tau_propagation["early tau propagation"]
LRP1_perturbation["LRP1 perturbation"] -->|modulates| trans_synaptic_tau_spread["trans-synaptic tau spread"]
LRP1["LRP1"] -->|regulates| tau_propagation["tau propagation"]
LRP1_1["LRP1"] -->|modulates| tau_uptake["tau uptake"]
LRP1_2["LRP1"] -->|causes| trans_synaptic_tau_spread_3["trans-synaptic tau spread"]
LRP1_blockade["LRP1 blockade"] -->|prevents| tau_spreading["tau spreading"]
LRP1_4["LRP1"] -->|activates| tau_propagation_cascade["tau propagation cascade"]
LRP1_inhibition["LRP1 inhibition"] -->|prevents| tau_propagation_5["tau propagation"]
style LRP1_mediated_tau_uptake_ fill:#4fc3f7,stroke:#333,color:#000
style early_tau_propagation fill:#4fc3f7,stroke:#333,color:#000
style LRP1_perturbation fill:#4fc3f7,stroke:#333,color:#000
style trans_synaptic_tau_spread fill:#4fc3f7,stroke:#333,color:#000
style LRP1 fill:#ce93d8,stroke:#333,color:#000
style tau_propagation fill:#4fc3f7,stroke:#333,color:#000
style LRP1_1 fill:#ce93d8,stroke:#333,color:#000
style tau_uptake fill:#4fc3f7,stroke:#333,color:#000
style LRP1_2 fill:#ce93d8,stroke:#333,color:#000
style trans_synaptic_tau_spread_3 fill:#4fc3f7,stroke:#333,color:#000
style LRP1_blockade fill:#4fc3f7,stroke:#333,color:#000
style tau_spreading fill:#4fc3f7,stroke:#333,color:#000
style LRP1_4 fill:#ce93d8,stroke:#333,color:#000
style tau_propagation_cascade fill:#4fc3f7,stroke:#333,color:#000
style LRP1_inhibition fill:#4fc3f7,stroke:#333,color:#000
style tau_propagation_5 fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for TAU yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for tau.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.