graph TD
    A["Misfolded Protein Seeds"] --> B["alpha-Synuclein Aggregation"]
    A --> C["Tau Fibrillization"]
    A --> D["TDP-43 Inclusion Formation"]

    B --> E["Cross-Seeding Between Proteins"]
    C --> E
    D --> E

    E --> F["Amplified Aggregate Toxicity"]
    F --> G["Neurodegeneration Spread"]

    H["DNAJB6 Co-chaperone"] --> I["J-Domain Binds HSP70"]
    I --> J["HSP70 ATPase Activation"]
    J --> K["Substrate Recognition"]

    K --> L["Bind Amyloid Nuclei"]
    L --> M["Block Fibril Elongation"]
    L --> N["Prevent Cross-Seeding"]

    O["DNAJB6 Upregulation Therapy"] --> P["Enhanced DNAJB6 Expression"]
    P --> Q["Increased HSP70 Recruitment"]
    Q --> R["Universal Anti-Aggregation"]

    R --> S["Inhibit alpha-Syn Fibrillization"]
    R --> T["Inhibit Tau Aggregation"]
    R --> U["Inhibit TDP-43 Inclusions"]

    S --> V["Pan-Neurodegenerative Protection"]
    T --> V
    U --> V

    style A fill:#4a1942,stroke:#ce93d8,color:#e0e0e0
    style H fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style R fill:#1a3a2a,stroke:#81c784,color:#e0e0e0
    style V fill:#2a3a1a,stroke:#c5e1a5,color:#e0e0e0