The question is likely underpowered or misleading unless analyses preserve the key strata: VEGF, GWAS, VEGF-. Averaging across these strata could convert a causal subpopulation effect into a weak association.
Curated pathway from expert analysis
flowchart TD
A["VEGF Family GWAS Signals<br/>AD Risk in Hippocampal Vascular Genes"]
B["Cell-State Specific Angiogenesis<br/>Endothelial vs Pericyte vs Astrocyte"]
C["Vascular-Neuronal Coupling States<br/>Neurovascular Unit Integrity"]
D["Hippocampal CA1 Vulnerability<br/>Region-Specific Stress Response"]
E["Epigenetic Aging Clock<br/>Hippocampal Cell-Type Methylation Patterns"]
F["AD Prevention<br/>Vascular Health Maintenance in Vulnerable Regions"]
A --> B
B --> C
C --> D
D --> E
E --> F
style A fill:#0d47a1,stroke:#64b5f6,color:#64b5f6
style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9aNo linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for GWAS yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for GWAS.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.