Thalamocortical circuits interface with para-arterial glymphatic influx pathways while corticopial projections interface with venous efflux. GluN2B-mediated thalamic activity preferentially shunts CSF toward deeper thalamocortical perivascular spaces; reduced GluN2B redirects flow superficially. Tau clearance efficiency depends on matching regional burden to appropriate drainage topology.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
GluN2B["GluN2B"] -->|regulates| thalamic_burst_firing["thalamic burst firing"]
slow_wave_oscillations["slow-wave oscillations"] -->|enhances| glymphatic_clearance["glymphatic_clearance"]
tau_pathology["tau_pathology"] -.->|inhibits| glymphatic_clearance_effi["glymphatic clearance efficiency"]
Trem2["Trem2"] -->|regulates| tau_phagocytosis["tau phagocytosis"]
TREM2_deficiency["TREM2 deficiency"] -->|associated with| Tau_Clearance["Tau Clearance"]
Cx3Cl1["Cx3Cl1"] -->|associated with| Cx3Cr1["Cx3Cr1"]
Cx3Cr1_1["Cx3Cr1"] -->|regulates| tau_phagocytosis_2["tau phagocytosis"]
Memantine["Memantine"] -->|enhances| CSF_tracer_clearance["CSF tracer clearance"]
GluN2B_3["GluN2B"] -->|associated with| cortical_slow_wave_oscill["cortical slow-wave oscillations"]
oxidative_stress["oxidative_stress"] -->|causes| AQP4_oxidation["AQP4 oxidation"]
GLUTAMATE_EXCITOTOXICITY["GLUTAMATE EXCITOTOXICITY"] -->|enhances| Tau_Secretion["Tau Secretion"]
sess_SRB_2026_04_28_h_var["sess_SRB-2026-04-28-h-var-e2b5a7e7db_task_9aae8fc5"] -->|causal extracted| processed["processed"]
style GluN2B fill:#4fc3f7,stroke:#333,color:#000
style thalamic_burst_firing fill:#4fc3f7,stroke:#333,color:#000
style slow_wave_oscillations fill:#4fc3f7,stroke:#333,color:#000
style glymphatic_clearance fill:#81c784,stroke:#333,color:#000
style tau_pathology fill:#ef5350,stroke:#333,color:#000
style glymphatic_clearance_effi fill:#4fc3f7,stroke:#333,color:#000
style Trem2 fill:#4fc3f7,stroke:#333,color:#000
style tau_phagocytosis fill:#4fc3f7,stroke:#333,color:#000
style TREM2_deficiency fill:#4fc3f7,stroke:#333,color:#000
style Tau_Clearance fill:#4fc3f7,stroke:#333,color:#000
style Cx3Cl1 fill:#4fc3f7,stroke:#333,color:#000
style Cx3Cr1 fill:#4fc3f7,stroke:#333,color:#000
style Cx3Cr1_1 fill:#4fc3f7,stroke:#333,color:#000
style tau_phagocytosis_2 fill:#4fc3f7,stroke:#333,color:#000
style Memantine fill:#ce93d8,stroke:#333,color:#000
style CSF_tracer_clearance fill:#ce93d8,stroke:#333,color:#000
style GluN2B_3 fill:#4fc3f7,stroke:#333,color:#000
style cortical_slow_wave_oscill fill:#4fc3f7,stroke:#333,color:#000
style oxidative_stress fill:#4fc3f7,stroke:#333,color:#000
style AQP4_oxidation fill:#4fc3f7,stroke:#333,color:#000
style GLUTAMATE_EXCITOTOXICITY fill:#4fc3f7,stroke:#333,color:#000
style Tau_Secretion fill:#4fc3f7,stroke:#333,color:#000
style sess_SRB_2026_04_28_h_var fill:#4fc3f7,stroke:#333,color:#000
style processed fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for GRIN2B activity pattern; topological glymphatic routing.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.