Maintain dendritic spine stability and synaptic plasticity in stellate neurons through Reelin pathway activation, preserving spatial navigation circuit integrity
Debate provenance: derived from debate `sess_sda-2026-04-01-gap-004` on question: Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique electrophysiological properties, grid cell function, and high metabolic demand may contribute, but the molecular basis of selective vulnerability is unknown.. Consensus signal: clinical_trialist, domain_expert, medicinal_chemist, synthesizer, theorist discussed the mechanism terms Enhancement, RELN, Reelin, Signaling, activation, signaling, synaptic. Novelty signal: synthesizer-consensus.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
RELN["RELN"] -->|encodes| reelin_protein["reelin_protein"]
RELN_1["RELN"] -->|regulates| Reelin_Mediated_Cytoskele["Reelin-Mediated Cytoskeletal Stabilization Protoco"]
RELN_2["RELN"] -->|regulates| Tau_Propagation["Tau Propagation"]
RELN_3["RELN"] -->|participates in| Reelin_signaling___cytosk["Reelin signaling / cytoskeletal regulation"]
RELN_4["RELN"] -->|co discussed| MAP6["MAP6"]
RELN_5["RELN"] -->|co discussed| HCN1["HCN1"]
RELN_6["RELN"] -->|co discussed| MCU["MCU"]
RELN_7["RELN"] -->|co discussed| IDH2["IDH2"]
PPARGC1A["PPARGC1A"] -->|co discussed| RELN_8["RELN"]
SLC16A2["SLC16A2"] -->|co discussed| RELN_9["RELN"]
RELN_10["RELN"] -->|co discussed| PPARGC1A_11["PPARGC1A"]
RELN_12["RELN"] -->|co discussed| SLC16A2_13["SLC16A2"]
MCU_14["MCU"] -->|co discussed| RELN_15["RELN"]
MAP6_16["MAP6"] -->|co discussed| RELN_17["RELN"]
IDH2_18["IDH2"] -->|co discussed| RELN_19["RELN"]
style RELN fill:#ce93d8,stroke:#333,color:#000
style reelin_protein fill:#4fc3f7,stroke:#333,color:#000
style RELN_1 fill:#ce93d8,stroke:#333,color:#000
style Reelin_Mediated_Cytoskele fill:#4fc3f7,stroke:#333,color:#000
style RELN_2 fill:#ce93d8,stroke:#333,color:#000
style Tau_Propagation fill:#4fc3f7,stroke:#333,color:#000
style RELN_3 fill:#ce93d8,stroke:#333,color:#000
style Reelin_signaling___cytosk fill:#81c784,stroke:#333,color:#000
style RELN_4 fill:#ce93d8,stroke:#333,color:#000
style MAP6 fill:#ce93d8,stroke:#333,color:#000
style RELN_5 fill:#ce93d8,stroke:#333,color:#000
style HCN1 fill:#ce93d8,stroke:#333,color:#000
style RELN_6 fill:#ce93d8,stroke:#333,color:#000
style MCU fill:#ce93d8,stroke:#333,color:#000
style RELN_7 fill:#ce93d8,stroke:#333,color:#000
style IDH2 fill:#ce93d8,stroke:#333,color:#000
style PPARGC1A fill:#ce93d8,stroke:#333,color:#000
style RELN_8 fill:#ce93d8,stroke:#333,color:#000
style SLC16A2 fill:#ce93d8,stroke:#333,color:#000
style RELN_9 fill:#ce93d8,stroke:#333,color:#000
style RELN_10 fill:#ce93d8,stroke:#333,color:#000
style PPARGC1A_11 fill:#ce93d8,stroke:#333,color:#000
style RELN_12 fill:#ce93d8,stroke:#333,color:#000
style SLC16A2_13 fill:#ce93d8,stroke:#333,color:#000
style MCU_14 fill:#ce93d8,stroke:#333,color:#000
style RELN_15 fill:#ce93d8,stroke:#333,color:#000
style MAP6_16 fill:#ce93d8,stroke:#333,color:#000
style RELN_17 fill:#ce93d8,stroke:#333,color:#000
style IDH2_18 fill:#ce93d8,stroke:#333,color:#000
style RELN_19 fill:#ce93d8,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for RELN yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for RELN.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.