Maternal-zygotic transition-like reprogramming between PSP and CBD
Debate provenance: derived from debate `sess_sda-2026-04-01-gap-005` on question: PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns (tufted astrocytes vs astrocytic plaques). Whether tau strains or regional cellular environments drive these differences is unresolved.. Consensus signal: clinical_trialist, domain_expert, skeptic, synthesizer, theorist discussed the mechanism terms CBD, PSP, Reprogramming, SOX2, Stage. Novelty signal: skeptic-discussed-with-qualified-concession.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
ATG7["ATG7"] -->|regulates| autophagy_pathway["autophagy_pathway"]
tau_protein["tau_protein"] -->|aggregates in| PSP["PSP"]
tau_protein_1["tau_protein"] -->|aggregates in| CBD["CBD"]
NFE2L2["NFE2L2"] -->|regulates| NRF2_pathway["NRF2_pathway"]
n4r_tau["4r-tau"] -->|causes| psp["psp"]
n4r_tau_2["4r-tau"] -->|causes| CBD_3["CBD"]
autophagy_pathway_4["autophagy_pathway"] -->|promotes| tau_clearance["tau_clearance"]
NRF2_pathway_5["NRF2_pathway"] -->|mediates| oxidative_stress_response["oxidative_stress_response"]
WNT_SIGNALING["WNT_SIGNALING"] -->|activates| CDC42["CDC42"]
WNT_SIGNALING_6["WNT_SIGNALING"] -->|activates| Rac1["Rac1"]
CDC42_7["CDC42"] -->|regulates| cytoskeletal_remodeling["cytoskeletal remodeling"]
Rac1_8["Rac1"] -->|regulates| cytoskeletal_remodeling_9["cytoskeletal remodeling"]
style ATG7 fill:#ce93d8,stroke:#333,color:#000
style autophagy_pathway fill:#81c784,stroke:#333,color:#000
style tau_protein fill:#4fc3f7,stroke:#333,color:#000
style PSP fill:#ef5350,stroke:#333,color:#000
style tau_protein_1 fill:#4fc3f7,stroke:#333,color:#000
style CBD fill:#ef5350,stroke:#333,color:#000
style NFE2L2 fill:#ce93d8,stroke:#333,color:#000
style NRF2_pathway fill:#81c784,stroke:#333,color:#000
style n4r_tau fill:#4fc3f7,stroke:#333,color:#000
style psp fill:#ef5350,stroke:#333,color:#000
style n4r_tau_2 fill:#4fc3f7,stroke:#333,color:#000
style CBD_3 fill:#4fc3f7,stroke:#333,color:#000
style autophagy_pathway_4 fill:#81c784,stroke:#333,color:#000
style tau_clearance fill:#4fc3f7,stroke:#333,color:#000
style NRF2_pathway_5 fill:#81c784,stroke:#333,color:#000
style oxidative_stress_response fill:#4fc3f7,stroke:#333,color:#000
style WNT_SIGNALING fill:#81c784,stroke:#333,color:#000
style CDC42 fill:#ce93d8,stroke:#333,color:#000
style WNT_SIGNALING_6 fill:#81c784,stroke:#333,color:#000
style Rac1 fill:#4fc3f7,stroke:#333,color:#000
style CDC42_7 fill:#ce93d8,stroke:#333,color:#000
style cytoskeletal_remodeling fill:#4fc3f7,stroke:#333,color:#000
style Rac1_8 fill:#4fc3f7,stroke:#333,color:#000
style cytoskeletal_remodeling_9 fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for SOX2 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for SOX2.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.