The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a proximal molecular phenotype, then a disease-relevant phenotype, in that order.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
VEGF_family_genes["VEGF family genes"] -->|associated with| Alzheimer_s_disease_endop["Alzheimer's disease endophenotypes"]
VEGF_variants["VEGF variants"] -->|regulates| hippocampal_vascular_neur["hippocampal vascular-neuronal coupling"]
VEGF_family_genetic_contr["VEGF-family genetic control"] -->|modulates| vascular_neuronal_couplin["vascular-neuronal coupling in vulnerable hippocampal regions"]
VEGF["VEGF"] -->|risk factor for| Alzheimer_s_disease["Alzheimer's disease"]
vascular_changes["vascular changes"] -->|associated with| neurodegeneration["neurodegeneration"]
sess_a7f528aa_20c4_409d_a["sess_a7f528aa-20c4-409d-a8c3-e2662850e63d_task_66f1207e_recon"] -->|causal extracted| processed["processed"]
style VEGF_family_genes fill:#ce93d8,stroke:#333,color:#000
style Alzheimer_s_disease_endop fill:#4fc3f7,stroke:#333,color:#000
style VEGF_variants fill:#ce93d8,stroke:#333,color:#000
style hippocampal_vascular_neur fill:#4fc3f7,stroke:#333,color:#000
style VEGF_family_genetic_contr fill:#4fc3f7,stroke:#333,color:#000
style vascular_neuronal_couplin fill:#4fc3f7,stroke:#333,color:#000
style VEGF fill:#ce93d8,stroke:#333,color:#000
style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#000
style vascular_changes fill:#4fc3f7,stroke:#333,color:#000
style neurodegeneration fill:#4fc3f7,stroke:#333,color:#000
style sess_a7f528aa_20c4_409d_a fill:#4fc3f7,stroke:#333,color:#000
style processed fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for VEGF- yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for VEGF-.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.