Astrocytic GABA transporter dysfunction may contribute to extracellular GABA changes, chloride-gradient disruption, and network hyperexcitability in ALS/FTD. The hypothesis is interesting but requires directionality testing because restoring uptake, inhibiting uptake, and region-specific modulation could have opposite effects.
No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for SLC6A13; yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for SLC6A13; SLC12A5; SLC12A2.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.