The consensus is to preserve this as a debated candidate, not a canonical world-model claim. Replication or rerun evidence should precede promotion into Atlas or market funding.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
APOE4["APOE4"] -->|causes| lipid_dysregulation["lipid dysregulation"]
APOE4_1["APOE4"] -->|causes| synaptic_phagocytosis["synaptic phagocytosis"]
APOE4_2["APOE4"] -->|risk factor for| AD["AD"]
lipid_dysregulation_3["lipid dysregulation"] -->|drives| AD_pathology["AD pathology"]
synaptic_phagocytosis_4["synaptic phagocytosis"] -->|drives| AD_pathology_5["AD pathology"]
APOE4_to_APOE3_correction["APOE4 to APOE3 correction"] -->|prevents| amyloid["amyloid"]
APOE4_to_APOE3_correction_6["APOE4 to APOE3 correction"] -->|modulates| synaptic_function["synaptic function"]
APOE_genotype["APOE genotype"] -->|associated with| AD_7["AD"]
neuron_microglia_astrocyt["neuron-microglia-astrocyte co-culture validation"] -->|regulates| APOE4_synaptic_causality["APOE4 synaptic causality"]
APOE4_8["APOE4"] -->|causes| amyloid_9["amyloid"]
amyloid_10["amyloid"] -->|biomarker for| AD_11["AD"]
microglia["microglia"] -->|regulates| synaptic_phagocytosis_12["synaptic phagocytosis"]
style APOE4 fill:#ce93d8,stroke:#333,color:#000
style lipid_dysregulation fill:#4fc3f7,stroke:#333,color:#000
style APOE4_1 fill:#ce93d8,stroke:#333,color:#000
style synaptic_phagocytosis fill:#4fc3f7,stroke:#333,color:#000
style APOE4_2 fill:#ce93d8,stroke:#333,color:#000
style AD fill:#ef5350,stroke:#333,color:#000
style lipid_dysregulation_3 fill:#4fc3f7,stroke:#333,color:#000
style AD_pathology fill:#4fc3f7,stroke:#333,color:#000
style synaptic_phagocytosis_4 fill:#4fc3f7,stroke:#333,color:#000
style AD_pathology_5 fill:#4fc3f7,stroke:#333,color:#000
style APOE4_to_APOE3_correction fill:#4fc3f7,stroke:#333,color:#000
style amyloid fill:#4fc3f7,stroke:#333,color:#000
style APOE4_to_APOE3_correction_6 fill:#4fc3f7,stroke:#333,color:#000
style synaptic_function fill:#4fc3f7,stroke:#333,color:#000
style APOE_genotype fill:#ce93d8,stroke:#333,color:#000
style AD_7 fill:#ef5350,stroke:#333,color:#000
style neuron_microglia_astrocyt fill:#4fc3f7,stroke:#333,color:#000
style APOE4_synaptic_causality fill:#4fc3f7,stroke:#333,color:#000
style APOE4_8 fill:#ce93d8,stroke:#333,color:#000
style amyloid_9 fill:#4fc3f7,stroke:#333,color:#000
style amyloid_10 fill:#4fc3f7,stroke:#333,color:#000
style AD_11 fill:#ef5350,stroke:#333,color:#000
style microglia fill:#4fc3f7,stroke:#333,color:#000
style synaptic_phagocytosis_12 fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for TAU yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for tau.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.