Claims from this analysis should be evaluated across TREM2, AD, tau, amyloid; pooled effects are insufficient when causal direction, cell state, genotype, benchmark leakage, or reproducibility risks can dominate the result.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
TREM2["TREM2"] -.->|inhibits| tau_spread["tau spread"]
TREM2_1["TREM2"] -->|modulates| AD_progression["AD progression"]
sess_AD_MASTER_PLAN_TREM2["sess_AD-MASTER-PLAN-TREM2-20260428030753_task_66f1207e_ctx"] -->|causal extracted| processed["processed"]
style TREM2 fill:#ce93d8,stroke:#333,color:#000
style tau_spread fill:#4fc3f7,stroke:#333,color:#000
style TREM2_1 fill:#ce93d8,stroke:#333,color:#000
style AD_progression fill:#4fc3f7,stroke:#333,color:#000
style sess_AD_MASTER_PLAN_TREM2 fill:#4fc3f7,stroke:#333,color:#000
style processed fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for AD yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for AD.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.