graph TD
    APOE__4["APOE ε4"] -->|risk factor for| Alzheimer_s_disease["Alzheimer's disease"]
    APOE__4_1["APOE ε4"] -->|regulates| microglial_lipid_handling["microglial lipid handling"]
    microglial_lipid_handling_2["microglial lipid handling dysfunction"] -->|associated with| Alzheimer_s_disease_progr["Alzheimer's disease progression"]
    non_neuronal_transcriptio["non-neuronal transcriptional changes"] -->|biomarker for| tau_propagation["tau propagation"]
    non_neuronal_cell_types["non-neuronal cell types"] -->|associated with| Alzheimer_s_disease_3["Alzheimer's disease"]
    cell_type_resolution_anal["cell-type resolution analysis"] -->|modulates| causal_subpopulation_effe["causal subpopulation effect detection"]
    bulk_amyloid_readouts["bulk amyloid readouts"] -->|modulates| subpopulation_specific_ef["subpopulation-specific effects"]
    perturbation_experiments["perturbation experiments"] -->|causes| causality_establishment["causality establishment"]
    spatial_transcriptomics_r["spatial transcriptomics resolution"] -->|enables| non_neuronal_dysregulatio["non-neuronal dysregulation pattern detection"]
    APOE__4_driven_microglial["APOE ε4-driven microglial lipid handling"] -->|causes| measurable_proximal_pheno["measurable proximal phenotype"]
    sess_db9a224d_3ebb_429c_8["sess_db9a224d-3ebb-429c-8f02-b703d71ca211_task_66f1207e_recon"] -->|causal extracted| processed["processed"]
    style APOE__4 fill:#ce93d8,stroke:#333,color:#000
    style Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#000
    style APOE__4_1 fill:#ce93d8,stroke:#333,color:#000
    style microglial_lipid_handling fill:#4fc3f7,stroke:#333,color:#000
    style microglial_lipid_handling_2 fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_s_disease_progr fill:#ef5350,stroke:#333,color:#000
    style non_neuronal_transcriptio fill:#4fc3f7,stroke:#333,color:#000
    style tau_propagation fill:#4fc3f7,stroke:#333,color:#000
    style non_neuronal_cell_types fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_s_disease_3 fill:#ef5350,stroke:#333,color:#000
    style cell_type_resolution_anal fill:#4fc3f7,stroke:#333,color:#000
    style causal_subpopulation_effe fill:#4fc3f7,stroke:#333,color:#000
    style bulk_amyloid_readouts fill:#4fc3f7,stroke:#333,color:#000
    style subpopulation_specific_ef fill:#4fc3f7,stroke:#333,color:#000
    style perturbation_experiments fill:#4fc3f7,stroke:#333,color:#000
    style causality_establishment fill:#4fc3f7,stroke:#333,color:#000
    style spatial_transcriptomics_r fill:#4fc3f7,stroke:#333,color:#000
    style non_neuronal_dysregulatio fill:#4fc3f7,stroke:#333,color:#000
    style APOE__4_driven_microglial fill:#4fc3f7,stroke:#333,color:#000
    style measurable_proximal_pheno fill:#4fc3f7,stroke:#333,color:#000
    style sess_db9a224d_3ebb_429c_8 fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000