NADPH depletion from PPP inhibition creates ferroptosis susceptibility in vulnerable neurons. Neurodegeneration-associated metabolic stress suppresses the pentose phosphate pathway, reducing NADPH availability. Without adequate NADPH to regenerate reduced glutathione, GPX4 activity becomes insufficient to detoxify lipid peroxides, rendering neurons susceptible to ferroptosis.
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No curated PDB or AlphaFold mapping for G6PD yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for G6PD, SLC7A11, GPX4.
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No resource usage or linked notebooks recorded for this hypothesis yet.