flowchart TD
    A["Protective Chromatin Remodeling<br/>Early Stress-Adaptive State"]
    B["H3K27ac Gain at Defense Loci<br/>NRF2 and FOXO3 Target Activation"]
    C["H3K9me3 Deployment<br/>Transposon and Repeat Silencing"]
    D["Stage-Dependent Transition<br/>Adaptive to Pathological Shift"]
    E["Late-Stage Heterochromatin Loss<br/>Progressive Chromatin Collapse"]
    F["Early Intervention Window<br/>Chromatin Reinforcement Strategy"]
    G["Epigenome Targeting Therapy<br/>HDAC Inhibitor or DNMT Modulator"]
    A --> B
    A --> C
    B --> D
    C --> D
    D --> E
    F -.->|"extends"| A
    G -.->|"implements"| F
    style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style D fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style E fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
    style G fill:#1b5e20,stroke:#81c784,color:#81c784