flowchart TD
    A["Endothelial Transcytosis<br/>Caveolae-Mediated Vesicular Route"]
    B["Caveolin-1 Scaffold<br/>Plasma Membrane Invagination"]
    C["Cargo Uptake<br/>Albumin IgG and Nanoparticles"]
    D["Intracellular Trafficking<br/>Early Endosome Routing"]
    E["Basolateral Release<br/>Parenchymal Delivery"]
    F["Therapeutic Delivery Window<br/>Early Stage Intervention Target"]
    G["Pathological Transcytosis<br/>Amyloid and Tau Seed Entry"]
    A --> B
    B --> C
    C --> D
    D --> E
    D --> G
    F -.->|"targets"| A
    style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style G fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
    style F fill:#1b5e20,stroke:#81c784,color:#81c784