flowchart TD
    A["Age-Linked CpG Drift<br/>Progressive Hypomethylation"]
    B["DNMT1 Maintenance Failure<br/>Replication-Linked Fidelity Loss"]
    C["Transposon Derepression<br/>LINE-1 and IAP Silencing Loss"]
    D["cGAS-STING Innate Sensing<br/>Cytosolic DNA Detection"]
    E["Heterochromatin Erosion<br/>H3K9me3 and H3K27me3 Loss"]
    F["SASP Cytokine Secretion<br/>Senescence-Associated Phenotype"]
    G["Glial Identity Drift<br/>Microglia and Astrocyte Dysregulation"]
    A --> B
    A --> C
    B --> E
    C --> D
    D --> F
    E --> G
    F --> G
    style A fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style D fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style F fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a
    style G fill:#b71c1c,stroke:#ef9a9a,color:#ef9a9a