flowchart TD
    A["Microglial Circadian Disruption<br/>Glycolytic Pro-Inflammatory Shift"]
    B["NAD+ Depletion<br/>SIRT1 SIRT3 Activity Impaired"]
    C["AMPK PRKAA1 Signaling Reduced<br/>Oxidative Metabolism Brake"]
    D["Timed NAD+ Precursor Delivery<br/>NMN NR at Circadian Peak"]
    E["AMPK Activator Administration<br/>AICAR Metformin at Trough"]
    F["Sirtuin Reactivation<br/>SIRT1 Deacetylase Restored"]
    G["PPARGC1A PGC1alpha Deacetylated<br/>Oxidative Phosphorylation Restored"]
    H["Anti-Inflammatory Microglial Phenotype<br/>Homeostatic Circadian Metabolism"]
    A --> B
    A --> C
    D --> F
    E --> C
    B --> F
    C --> G
    F --> G
    G --> H
    style G fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style H fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7