graph TD
    ARNTL["ARNTL"] -->|transcriptionally| NLRP3["NLRP3"]
    circadian_disruption["circadian disruption"] -->|causes| neuroinflammation["neuroinflammation"]
    IL1R1["IL1R1"] -->|mediates| Microglial_priming["Microglial priming"]
    anti_TNF_drugs["anti-TNF drugs"] -->|targets| neuroinflammation_1["neuroinflammation"]
    inflammation["inflammation"] -->|causes| Microglial_priming_2["Microglial priming"]
    microglial_priming["microglial_priming"] -->|causes| neurodegeneration["neurodegeneration"]
    NR1D1["NR1D1"] -->|represses| NFKB1["NFKB1"]
    IL1R1_3["IL1R1"] -->|mediates| microglial_priming_4["microglial_priming"]
    circadian_disruption_5["circadian_disruption"] -->|causes| neuroinflammation_6["neuroinflammation"]
    CSNK1D["CSNK1D"] -->|phosphorylates| PER1["PER1"]
    MMP9["MMP9"] -->|remodels| extracellular_matrix["extracellular_matrix"]
    IL1R1_7["IL1R1"] -->|modulates| positive_feedback_loops["positive_feedback_loops"]
    style ARNTL fill:#ce93d8,stroke:#333,color:#000
    style NLRP3 fill:#ce93d8,stroke:#333,color:#000
    style circadian_disruption fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
    style IL1R1 fill:#ce93d8,stroke:#333,color:#000
    style Microglial_priming fill:#4fc3f7,stroke:#333,color:#000
    style anti_TNF_drugs fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation_1 fill:#4fc3f7,stroke:#333,color:#000
    style inflammation fill:#4fc3f7,stroke:#333,color:#000
    style Microglial_priming_2 fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration fill:#ef5350,stroke:#333,color:#000
    style NR1D1 fill:#ce93d8,stroke:#333,color:#000
    style NFKB1 fill:#ce93d8,stroke:#333,color:#000
    style IL1R1_3 fill:#ce93d8,stroke:#333,color:#000
    style microglial_priming_4 fill:#4fc3f7,stroke:#333,color:#000
    style circadian_disruption_5 fill:#4fc3f7,stroke:#333,color:#000
    style neuroinflammation_6 fill:#4fc3f7,stroke:#333,color:#000
    style CSNK1D fill:#ce93d8,stroke:#333,color:#000
    style PER1 fill:#ce93d8,stroke:#333,color:#000
    style MMP9 fill:#ce93d8,stroke:#333,color:#000
    style extracellular_matrix fill:#81c784,stroke:#333,color:#000
    style IL1R1_7 fill:#ce93d8,stroke:#333,color:#000
    style positive_feedback_loops fill:#4fc3f7,stroke:#333,color:#000