flowchart TD
    A["APOE4 Microglial Metabolic Crisis<br/>Energetic Insufficiency"]
    B["CD38 NADase Overactivation<br/>NAD+ Hydrolysis Accelerated"]
    C["NAMPT Rate-Limiting Salvage<br/>NMN Synthesis Reduced"]
    D["NAD+ Pool Depletion<br/>Below Sirtuin Activation Threshold"]
    E["SIRT1 SIRT3 Activity Falls<br/>Mitochondrial Function Impaired"]
    F["CD38 Inhibitor Treatment<br/>78c or Apigenin Administration"]
    G["NAMPT Enhancer Treatment<br/>P7C3 or FK866 Inverse Agonist"]
    H["NAD+ Levels Restored<br/>SIRT1 SIRT3 Reactivated"]
    I["Oxidative Phosphorylation Restored<br/>APOE4 Microglial Function Rescued"]
    A --> B
    A --> C
    B --> D
    C --> D
    D --> E
    F -.->|"rescues NAD+"| D
    G --> C
    F --> H
    G --> H
    H --> E
    E --> I
    style D fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
    style I fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7