Enhance MCT1/MCT2 expression to convert metabolic lactate overproduction into alternative fuel source for high-demand states like amyloid clearance
Auto-built from this analysis's top knowledge-graph edges.
graph TD
NAD__biosynthesis["NAD+ biosynthesis"] -->|activates| sirtuin_function["sirtuin function"]
TREM2["TREM2"] -->|mediates| amyloid_clearance["amyloid clearance"]
NAMPT["NAMPT"] -->|associated with| Nad__Biosynthesis["Nad+ Biosynthesis"]
Nad__Biosynthesis_1["Nad+ Biosynthesis"] -->|associated with| sirtuin_function_2["sirtuin function"]
apoe4["apoe4"] -->|causes| metabolic_crisis["metabolic crisis"]
APOE4["APOE4"] -.->|inhibits| NAMPT_3["NAMPT"]
APOE4_4["APOE4"] -->|activates| MTOR_signaling["MTOR signaling"]
MTOR["MTOR"] -->|regulates| metabolic_flexibility["metabolic flexibility"]
APOE4_5["APOE4"] -->|causes| lipid_droplet_formation["lipid droplet formation"]
DGAT1["DGAT1"] -->|catalyzes| lipid_droplet_formation_6["lipid droplet formation"]
APOE4_7["APOE4"] -->|disrupts| mitochondrial_ER_contacts["mitochondrial-ER contacts"]
VDAC1["VDAC1"] -->|regulates| mitochondrial_ER_contacts_8["mitochondrial-ER contacts"]
style NAD__biosynthesis fill:#81c784,stroke:#333,color:#000
style sirtuin_function fill:#4fc3f7,stroke:#333,color:#000
style TREM2 fill:#4fc3f7,stroke:#333,color:#000
style amyloid_clearance fill:#4fc3f7,stroke:#333,color:#000
style NAMPT fill:#ce93d8,stroke:#333,color:#000
style Nad__Biosynthesis fill:#81c784,stroke:#333,color:#000
style Nad__Biosynthesis_1 fill:#81c784,stroke:#333,color:#000
style sirtuin_function_2 fill:#4fc3f7,stroke:#333,color:#000
style apoe4 fill:#ef5350,stroke:#333,color:#000
style metabolic_crisis fill:#4fc3f7,stroke:#333,color:#000
style APOE4 fill:#ce93d8,stroke:#333,color:#000
style NAMPT_3 fill:#ce93d8,stroke:#333,color:#000
style APOE4_4 fill:#ce93d8,stroke:#333,color:#000
style MTOR_signaling fill:#81c784,stroke:#333,color:#000
style MTOR fill:#4fc3f7,stroke:#333,color:#000
style metabolic_flexibility fill:#4fc3f7,stroke:#333,color:#000
style APOE4_5 fill:#ce93d8,stroke:#333,color:#000
style lipid_droplet_formation fill:#4fc3f7,stroke:#333,color:#000
style DGAT1 fill:#4fc3f7,stroke:#333,color:#000
style lipid_droplet_formation_6 fill:#4fc3f7,stroke:#333,color:#000
style APOE4_7 fill:#ce93d8,stroke:#333,color:#000
style mitochondrial_ER_contacts fill:#4fc3f7,stroke:#333,color:#000
style VDAC1 fill:#4fc3f7,stroke:#333,color:#000
style mitochondrial_ER_contacts_8 fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for SLC16A1 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for SLC16A1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.