In AD, TNF-α/IL-6 maintain critical astrocyte-mediated glucose metabolism and lactate shuttling to neurons. Cardiovascular tissues have alternative metabolic pathways, making them less dependent on these cytokine-regulated metabolic circuits.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
TNFRSF1B["TNFRSF1B"] -->|regulates| synaptic_plasticity["synaptic_plasticity"]
LRP1["LRP1"] -->|regulates| blood_brain_barrier["blood_brain_barrier"]
SLC16A7["SLC16A7"] -->|modulates| lactate_shuttling["lactate_shuttling"]
AQP4["AQP4"] -->|regulates| glymphatic_system["glymphatic_system"]
NLRP3["NLRP3"] -->|activates| inflammasome_activation["inflammasome_activation"]
neuroinflammation["neuroinflammation"] -->|causes| alzheimer_disease["alzheimer_disease"]
TNF["TNF"] -->|enhances| neuroinflammation_1["neuroinflammation"]
IL6["IL6"] -->|enhances| neuroinflammation_2["neuroinflammation"]
NLRP3_3["NLRP3"] -->|enhances| neuroinflammation_4["neuroinflammation"]
TNF_5["TNF"] -->|regulates| glymphatic_clearance["glymphatic_clearance"]
IL6_6["IL6"] -->|regulates| glymphatic_clearance_7["glymphatic_clearance"]
TNF_8["TNF"] -->|regulates| glucose_metabolism["glucose_metabolism"]
style TNFRSF1B fill:#ce93d8,stroke:#333,color:#000
style synaptic_plasticity fill:#4fc3f7,stroke:#333,color:#000
style LRP1 fill:#ce93d8,stroke:#333,color:#000
style blood_brain_barrier fill:#4fc3f7,stroke:#333,color:#000
style SLC16A7 fill:#ce93d8,stroke:#333,color:#000
style lactate_shuttling fill:#81c784,stroke:#333,color:#000
style AQP4 fill:#ce93d8,stroke:#333,color:#000
style glymphatic_system fill:#81c784,stroke:#333,color:#000
style NLRP3 fill:#ce93d8,stroke:#333,color:#000
style inflammasome_activation fill:#81c784,stroke:#333,color:#000
style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
style alzheimer_disease fill:#ef5350,stroke:#333,color:#000
style TNF fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation_1 fill:#4fc3f7,stroke:#333,color:#000
style IL6 fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation_2 fill:#4fc3f7,stroke:#333,color:#000
style NLRP3_3 fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation_4 fill:#4fc3f7,stroke:#333,color:#000
style TNF_5 fill:#ce93d8,stroke:#333,color:#000
style glymphatic_clearance fill:#81c784,stroke:#333,color:#000
style IL6_6 fill:#ce93d8,stroke:#333,color:#000
style glymphatic_clearance_7 fill:#81c784,stroke:#333,color:#000
style TNF_8 fill:#ce93d8,stroke:#333,color:#000
style glucose_metabolism fill:#81c784,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for SLC16A7 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for SLC16A7.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.