TNF-α/IL-6 inhibition is beneficial in early/prodromal AD but harmful in established disease when these cytokines support neuronal survival and repair. Cardiovascular applications target chronic inflammation without this temporal sensitivity.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
TNFRSF1B["TNFRSF1B"] -->|regulates| synaptic_plasticity["synaptic_plasticity"]
TNF["TNF"] -->|enhances| neuroinflammation["neuroinflammation"]
TNF_1["TNF"] -->|regulates| glymphatic_clearance["glymphatic_clearance"]
TNF_2["TNF"] -->|regulates| glucose_metabolism["glucose_metabolism"]
TNFRSF1B_3["TNFRSF1B"] -->|regulates| SYNAPTIC_PLASTICITY["SYNAPTIC_PLASTICITY"]
TNF_4["TNF"] -->|associated with| Synaptic_Scaling["Synaptic Scaling"]
TNF_5["TNF"] -->|causes| Therapeutic_Resistance["Therapeutic Resistance"]
style TNFRSF1B fill:#ce93d8,stroke:#333,color:#000
style synaptic_plasticity fill:#4fc3f7,stroke:#333,color:#000
style TNF fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
style TNF_1 fill:#ce93d8,stroke:#333,color:#000
style glymphatic_clearance fill:#81c784,stroke:#333,color:#000
style TNF_2 fill:#ce93d8,stroke:#333,color:#000
style glucose_metabolism fill:#81c784,stroke:#333,color:#000
style TNFRSF1B_3 fill:#ce93d8,stroke:#333,color:#000
style SYNAPTIC_PLASTICITY fill:#4fc3f7,stroke:#333,color:#000
style TNF_4 fill:#ce93d8,stroke:#333,color:#000
style Synaptic_Scaling fill:#4fc3f7,stroke:#333,color:#000
style TNF_5 fill:#ce93d8,stroke:#333,color:#000
style Therapeutic_Resistance fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for TNF.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.