Convergent myelopathy phenotype results from disruption of S1P gradient that maintains immune cell trafficking and barrier function in spinal cord, with different etiologies converging by altering S1P metabolism.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
Fingolimod["Fingolimod"] -->|associated with| S1PR1["S1PR1"]
siponimod["siponimod"] -->|associated with| S1PR1_1["S1PR1"]
S1PR1_2["S1PR1"] -->|controls| immune_cell_trafficking["immune cell trafficking"]
S1PR1_3["S1PR1"] -->|maintains| blood_spinal_cord_barrier["blood-spinal cord barrier"]
S1PR1_4["S1PR1"] -->|associated with| immune_cell_trafficking_5["immune cell trafficking"]
S1PR1_6["S1PR1"] -->|associated with| blood_brain_barrier["blood_brain_barrier"]
style Fingolimod fill:#4fc3f7,stroke:#333,color:#000
style S1PR1 fill:#4fc3f7,stroke:#333,color:#000
style siponimod fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_1 fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_2 fill:#ce93d8,stroke:#333,color:#000
style immune_cell_trafficking fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_3 fill:#ce93d8,stroke:#333,color:#000
style blood_spinal_cord_barrier fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_4 fill:#4fc3f7,stroke:#333,color:#000
style immune_cell_trafficking_5 fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_6 fill:#4fc3f7,stroke:#333,color:#000
style blood_brain_barrier fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for S1PR1 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for S1PR1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.