Blood-spinal cord barrier breakdown represents mechanistic convergence point for diverse myelopathy etiologies, leading to stereotyped cascade of vascular dysfunction, protein extravasation, and secondary inflammation.
Curated pathway from expert analysis
flowchart TD
A["Diverse Spinal Cord Injury Triggers<br/>ALS Trauma Ischemia Compression"]
B["Spinal Vascular Unit Disruption<br/>Blood-Spinal Cord Barrier Breakdown"]
C["Pericyte Loss<br/>Endothelial Tight Junction Degradation"]
D["VEGFA Dysregulation<br/>Pro-Angiogenic Signaling Imbalance"]
E["Pathological Neovascularization<br/>Leaky Immature Vessel Formation"]
F["Serum Protein Extravasation<br/>Complement Albumin Fibrinogen Influx"]
G["Secondary Neuroinflammatory Cascade<br/>Universal Spinal Cord Pathology"]
H["Anti-VEGFA Combination Therapy<br/>Bevacizumab or Aflibercept"]
I["Vascular Stabilization<br/>Pericyte Coverage Restored"]
A --> B
B --> C
C --> D
D --> E
E --> F
F --> G
H -.->|"normalizes VEGFA"| D
H --> I
style D fill:#7b1fa2,stroke:#ce93d8,color:#ce93d8
style I fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for VEGFA yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for VEGFA.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.