Different myelopathy etiologies trigger conserved oligodendrocyte stress response program mediated by ER stress and integrated stress response, leading to stereotyped demyelination patterns.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
C5AR1["C5AR1"] -->|mediates| Complement_activation["Complement activation"]
Complement_activation_1["Complement activation"] -->|associated with| neuroinflammation["neuroinflammation"]
Fingolimod["Fingolimod"] -->|associated with| S1PR1["S1PR1"]
siponimod["siponimod"] -->|associated with| S1PR1_2["S1PR1"]
eculizumab["eculizumab"] -.->|inhibits| Complement_activation_3["Complement activation"]
avacopan["avacopan"] -.->|inhibits| C5AR1_4["C5AR1"]
C5AR1_5["C5AR1"] -->|mediates| complement_activation["complement activation"]
complement_activation_6["complement activation"] -->|drives| neuroinflammation_7["neuroinflammation"]
neuroinflammation_8["neuroinflammation"] -->|causes| myelopathy["myelopathy"]
S1PR1_9["S1PR1"] -->|controls| immune_cell_trafficking["immune cell trafficking"]
S1PR1_10["S1PR1"] -->|maintains| blood_spinal_cord_barrier["blood-spinal cord barrier"]
VEGFA["VEGFA"] -->|increases| vascular_permeability["vascular permeability"]
style C5AR1 fill:#ce93d8,stroke:#333,color:#000
style Complement_activation fill:#81c784,stroke:#333,color:#000
style Complement_activation_1 fill:#81c784,stroke:#333,color:#000
style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
style Fingolimod fill:#4fc3f7,stroke:#333,color:#000
style S1PR1 fill:#4fc3f7,stroke:#333,color:#000
style siponimod fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_2 fill:#4fc3f7,stroke:#333,color:#000
style eculizumab fill:#4fc3f7,stroke:#333,color:#000
style Complement_activation_3 fill:#81c784,stroke:#333,color:#000
style avacopan fill:#4fc3f7,stroke:#333,color:#000
style C5AR1_4 fill:#ce93d8,stroke:#333,color:#000
style C5AR1_5 fill:#ce93d8,stroke:#333,color:#000
style complement_activation fill:#81c784,stroke:#333,color:#000
style complement_activation_6 fill:#81c784,stroke:#333,color:#000
style neuroinflammation_7 fill:#4fc3f7,stroke:#333,color:#000
style neuroinflammation_8 fill:#4fc3f7,stroke:#333,color:#000
style myelopathy fill:#ef5350,stroke:#333,color:#000
style S1PR1_9 fill:#ce93d8,stroke:#333,color:#000
style immune_cell_trafficking fill:#4fc3f7,stroke:#333,color:#000
style S1PR1_10 fill:#ce93d8,stroke:#333,color:#000
style blood_spinal_cord_barrier fill:#4fc3f7,stroke:#333,color:#000
style VEGFA fill:#ce93d8,stroke:#333,color:#000
style vascular_permeability fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for EIF2AK3 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for EIF2AK3.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.