Circulating C1Q from atherosclerotic plaques crosses a compromised blood-brain barrier and primes microglial SPI1 expression, creating neuroinflammatory memory that predisposes to neurodegeneration. Anti-C1Q biologics could prevent this vascular-to-brain inflammatory transmission.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
C1Q["C1Q"] -->|participates in| complement_cascade["complement_cascade"]
SPI1["SPI1"] -->|regulates| C1Q_1["C1Q"]
C1Q_2["C1Q"] -->|crosses| blood_brain_barrier["blood-brain_barrier"]
C1Q_3["C1Q"] -->|enhances| SPI1_4["SPI1"]
C1q["C1q"] -->|activates| microglial_SPI1_expressio["microglial SPI1 expression"]
style C1Q fill:#ce93d8,stroke:#333,color:#000
style complement_cascade fill:#81c784,stroke:#333,color:#000
style SPI1 fill:#ce93d8,stroke:#333,color:#000
style C1Q_1 fill:#ce93d8,stroke:#333,color:#000
style C1Q_2 fill:#ce93d8,stroke:#333,color:#000
style blood_brain_barrier fill:#4fc3f7,stroke:#333,color:#000
style C1Q_3 fill:#ce93d8,stroke:#333,color:#000
style SPI1_4 fill:#ce93d8,stroke:#333,color:#000
style C1q fill:#4fc3f7,stroke:#333,color:#000
style microglial_SPI1_expressio fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for C1Q yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for C1Q.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.