SPI1 directly regulates C1Q expression in brain microglia, creating a feed-forward loop that amplifies neuroinflammation in cerebrovascular disease. Selective inhibition of SPI1 binding to C1Q promoter regions could break this pathological circuit while preserving beneficial microglial functions.
Auto-built from this analysis's top knowledge-graph edges.
graph TD
SPI1["SPI1"] -->|encodes| PU_1["PU.1"]
SPI1_1["SPI1"] -->|regulates| C1Q["C1Q"]
SPI1_2["SPI1"] -->|contributes to| neuroinflammation["neuroinflammation"]
SPI1_3["SPI1"] -->|regulates| glycolytic_metabolism["glycolytic_metabolism"]
SPI1_4["SPI1"] -->|regulates| microglia["microglia"]
C1Q_5["C1Q"] -->|enhances| SPI1_6["SPI1"]
SPI1_7["SPI1"] -->|causes| neuroinflammatory_memory["neuroinflammatory_memory"]
SPI1_8["SPI1"] -.->|inhibits| synaptic_plasticity["synaptic_plasticity"]
SPI1_9["SPI1"] -->|orchestrates| neurovascular_unit["neurovascular_unit"]
SPI1_10["SPI1"] -->|amplifies| neuroinflammation_11["neuroinflammation"]
SPI1_12["SPI1"] -->|modulates| chromatin_accessibility["chromatin_accessibility"]
chronic_vascular_inflamma["chronic_vascular_inflammation"] -->|regulates| SPI1_13["SPI1"]
SPI1_14["SPI1"] -->|maintains| microglial_activation["microglial_activation"]
SPI1_15["SPI1"] -->|associated with| atherosclerosis["atherosclerosis"]
SPI1_16["SPI1"] -->|regulates| Inflammatory_gene_express["Inflammatory gene expression"]
style SPI1 fill:#ce93d8,stroke:#333,color:#000
style PU_1 fill:#4fc3f7,stroke:#333,color:#000
style SPI1_1 fill:#ce93d8,stroke:#333,color:#000
style C1Q fill:#ce93d8,stroke:#333,color:#000
style SPI1_2 fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation fill:#4fc3f7,stroke:#333,color:#000
style SPI1_3 fill:#ce93d8,stroke:#333,color:#000
style glycolytic_metabolism fill:#81c784,stroke:#333,color:#000
style SPI1_4 fill:#ce93d8,stroke:#333,color:#000
style microglia fill:#4fc3f7,stroke:#333,color:#000
style C1Q_5 fill:#ce93d8,stroke:#333,color:#000
style SPI1_6 fill:#ce93d8,stroke:#333,color:#000
style SPI1_7 fill:#ce93d8,stroke:#333,color:#000
style neuroinflammatory_memory fill:#4fc3f7,stroke:#333,color:#000
style SPI1_8 fill:#ce93d8,stroke:#333,color:#000
style synaptic_plasticity fill:#4fc3f7,stroke:#333,color:#000
style SPI1_9 fill:#ce93d8,stroke:#333,color:#000
style neurovascular_unit fill:#4fc3f7,stroke:#333,color:#000
style SPI1_10 fill:#ce93d8,stroke:#333,color:#000
style neuroinflammation_11 fill:#4fc3f7,stroke:#333,color:#000
style SPI1_12 fill:#ce93d8,stroke:#333,color:#000
style chromatin_accessibility fill:#4fc3f7,stroke:#333,color:#000
style chronic_vascular_inflamma fill:#4fc3f7,stroke:#333,color:#000
style SPI1_13 fill:#ce93d8,stroke:#333,color:#000
style SPI1_14 fill:#ce93d8,stroke:#333,color:#000
style microglial_activation fill:#4fc3f7,stroke:#333,color:#000
style SPI1_15 fill:#ce93d8,stroke:#333,color:#000
style atherosclerosis fill:#ef5350,stroke:#333,color:#000
style SPI1_16 fill:#ce93d8,stroke:#333,color:#000
style Inflammatory_gene_express fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for SPI1 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for SPI1.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.