Therapeutic fine-tuning of lysosomal pH through v-ATPase modulation to optimize seed degradation while preventing toxic fragment formation
Auto-built from this analysis's top knowledge-graph edges.
graph TD
ATP6V1A["ATP6V1A"] -->|encodes subunit of| v_ATPase["v-ATPase"]
ATP6V1A_1["ATP6V1A"] -->|encodes subunit of| lysosomal_acidification["lysosomal acidification"]
ATP6V1A_2["ATP6V1A"] -->|associated with| neurodegeneration["neurodegeneration"]
style ATP6V1A fill:#ce93d8,stroke:#333,color:#000
style v_ATPase fill:#4fc3f7,stroke:#333,color:#000
style ATP6V1A_1 fill:#ce93d8,stroke:#333,color:#000
style lysosomal_acidification fill:#81c784,stroke:#333,color:#000
style ATP6V1A_2 fill:#ce93d8,stroke:#333,color:#000
style neurodegeneration fill:#ef5350,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for ATP6V1A yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for ATP6V1A.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.