Enhancement of mitochondrial-cytosolic proteostasis coupling through UPRmt activation to resist seed-induced protein misfolding cascades
Auto-built from this analysis's top knowledge-graph edges.
graph TD
ATP6V1A["ATP6V1A"] -->|encodes subunit of| v_ATPase["v-ATPase"]
ATP6V1A_1["ATP6V1A"] -->|encodes subunit of| lysosomal_acidification["lysosomal acidification"]
lysosomal_acidification_2["lysosomal acidification"] -->|associated with| PROTEIN_DEGRADATION["PROTEIN_DEGRADATION"]
HSPA1A["HSPA1A"] -->|regulates| PROTEIN_FOLDING["PROTEIN_FOLDING"]
PROTEIN_FOLDING_3["PROTEIN_FOLDING"] -.->|inhibits| PROTEIN_AGGREGATION["PROTEIN_AGGREGATION"]
v_ATPase_4["v-ATPase"] -->|modulates| lysosomal_pH["lysosomal pH"]
lysosomal_acidification_5["lysosomal acidification"] -->|enables| protein_degradation["protein degradation"]
protein_degradation_6["protein degradation"] -->|protects against| neurodegeneration["neurodegeneration"]
ATF5["ATF5"] -->|transcriptional ac| UPRmt["UPRmt"]
UPRmt_7["UPRmt"] -->|regulates| mitochondrial_proteostasi["mitochondrial proteostasis"]
mitochondrial_proteostasi_8["mitochondrial proteostasis"] -->|resists| seed_induced_protein_misf["seed-induced protein misfolding"]
HSPA1A_9["HSPA1A"] -->|facilitates| protein_folding["protein folding"]
style ATP6V1A fill:#ce93d8,stroke:#333,color:#000
style v_ATPase fill:#4fc3f7,stroke:#333,color:#000
style ATP6V1A_1 fill:#ce93d8,stroke:#333,color:#000
style lysosomal_acidification fill:#81c784,stroke:#333,color:#000
style lysosomal_acidification_2 fill:#81c784,stroke:#333,color:#000
style PROTEIN_DEGRADATION fill:#81c784,stroke:#333,color:#000
style HSPA1A fill:#ce93d8,stroke:#333,color:#000
style PROTEIN_FOLDING fill:#4fc3f7,stroke:#333,color:#000
style PROTEIN_FOLDING_3 fill:#4fc3f7,stroke:#333,color:#000
style PROTEIN_AGGREGATION fill:#4fc3f7,stroke:#333,color:#000
style v_ATPase_4 fill:#4fc3f7,stroke:#333,color:#000
style lysosomal_pH fill:#4fc3f7,stroke:#333,color:#000
style lysosomal_acidification_5 fill:#81c784,stroke:#333,color:#000
style protein_degradation fill:#4fc3f7,stroke:#333,color:#000
style protein_degradation_6 fill:#4fc3f7,stroke:#333,color:#000
style neurodegeneration fill:#ef5350,stroke:#333,color:#000
style ATF5 fill:#ce93d8,stroke:#333,color:#000
style UPRmt fill:#81c784,stroke:#333,color:#000
style UPRmt_7 fill:#81c784,stroke:#333,color:#000
style mitochondrial_proteostasi fill:#4fc3f7,stroke:#333,color:#000
style mitochondrial_proteostasi_8 fill:#4fc3f7,stroke:#333,color:#000
style seed_induced_protein_misf fill:#4fc3f7,stroke:#333,color:#000
style HSPA1A_9 fill:#ce93d8,stroke:#333,color:#000
style protein_folding fill:#4fc3f7,stroke:#333,color:#000No linked papers recorded for this hypothesis yet.
No curated PDB or AlphaFold mapping for ATF5 yet. Search RCSB →
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for ATF5.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.