flowchart TD
    A["Microglial Dysfunction<br/>AD Neuroinflammation"]
    B["TREM2 Signaling Activation<br/>Lipid Phagocytosis Enhancement"]
    C["APOE Modulation<br/>Cholesterol Efflux Optimization"]
    D["CLU Clusterin Activity<br/>Amyloid Chaperone and Clearance"]
    E["Combinatorial Network Targeting<br/>TREM2 plus APOE plus CLU"]
    F["Metabolic Reprogramming<br/>Anti-Inflammatory Microglial Phenotype"]
    G["Amyloid and Lipid Burden Cleared<br/>Neuroinflammation Resolved"]
    H["Neuroprotective Microglial State<br/>AD Progression Slowed"]
    A --> B
    A --> C
    A --> D
    B --> E
    C --> E
    D --> E
    E --> F
    F --> G
    G --> H
    style E fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style H fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7