flowchart TD
    A["Disease Stage Assessment<br/>Plasma CSF Biomarker Panel"]
    B["Early AD Stage<br/>Low Amyloid Tau Burden"]
    C["Late AD Stage<br/>High Amyloid Tau Burden"]
    D["TREM2 Agonist Treatment<br/>AL002c Anti-TREM2 Antibody"]
    E["TREM2 Pathway Modulation<br/>TYROBP-SYK-PI3K Signaling"]
    F["Microglial Phagocytosis Enhanced<br/>Amyloid Plaque Clearance"]
    G["Anti-Inflammatory Phenotype<br/>DAM Homeostatic Balance"]
    H["TREM2 Partial Antagonist<br/>Reduce Excessive Microglial Activation"]
    I["Neuroprotection via Timing<br/>AD Progression Slowed"]
    A --> B
    A --> C
    B --> D
    C --> H
    D --> E
    E --> F
    F --> G
    H --> G
    G --> I
    style E fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7
    style I fill:#1b5e20,stroke:#a5d6a7,color:#a5d6a7