Microglial Activation Model — AD Inflammation Dynamics

🧮 Model Details Biophysical

Internalcandidate

PARAMETERS

M_max	500.0
k_act	0.01
k_prod	0.1
k_clear	0.05
k_deact	0.03
k_phago	0.02
k_degrade	0.1
k_secrete	0.5

METRICS

parameters

{'M_max': 500.0, 'k_act': 0.01, 'k_prod': 0.1, 'k_clear': 0.05, 'k_deact': 0.03, 'k_phago': 0.02, 'k_degrade': 0.1, 'k_secrete': 0.5}

benchmark_name

Microglial-Amyloid ODE Inflammation Dynamics

benchmark_notes

6-reaction ODE system; 100hr time-span; healthy vs disease parameter regimes

EVALUATION CONTEXT

Dataset:In silico — time-course simulation validated against published microglial activation kinetics (Gomez-Nicola & Perry, 2015; Heneka et al., 2015)

Benchmark:Microglial-Amyloid ODE Inflammation Dynamics

Training data:Parameters sourced from SciDEX KG (KG:amyloid_production_rate, KG:enzymatic_clearance, KG:activation_threshold) and published neuroinflammation kinetics

SPECIES

Amyloid-βActivated microgliaPro-inflammatory cytokines